PTGER 基因家族多态性与韩国哮喘患者阿司匹林不耐受哮喘的关联。
Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics.
机构信息
Department of Life Science, Sogang University, Seoul, Korea.
出版信息
BMB Rep. 2010 Jun;43(6):445-9. doi: 10.5483/bmbrep.2010.43.6.445.
Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs. In this study, we investigated the relationship between Prostaglandin E2 receptor (PTGER) gene family polymorphisms and AIA in 243 AIA patients and 919 aspirin-tolerant asthma (ATA) controls of Korean ethnicity in two separate study cohorts. After genotyping 120 SNPs of the PTGER gene family for the 1(st) cohort study, four SNPs in PTGER1, ten in PTGER3, six in PTGER3, and a haplotype of PTGER2 showed association signals with decreased or increased risk of AIA. Among the positively associated SNPs, one in PTGER1 and four in PTGER3 were analyzed in the 2(nd) cohort study. The results show that rs7543182 and rs959 in PTGER3 retained their effect, although no statistical significance was retained in the 2(nd) cohort study. Our findings provide further evidence that polymorphisms in PTGER3 might play a significant role in aspirin hypersensitivity among Korean asthmatics.
阿司匹林不耐受型哮喘（AIA）的特征是在摄入阿司匹林和/或非甾体抗炎药后发生严重哮喘发作。在这项研究中，我们在两个独立的研究队列中，调查了前列腺素 E2 受体（PTGER）基因家族多态性与韩国裔 243 名 AIA 患者和 919 名阿司匹林耐受型哮喘（ATA）对照者之间的关系。在 1（st）队列研究中对 PTGER 基因家族的 120 个 SNP 进行基因分型后，PTGER1 中的 4 个 SNP、PTGER3 中的 10 个 SNP、PTGER3 中的 6 个 SNP 和 PTGER2 的单倍型显示与 AIA 风险降低或增加相关。在阳性相关 SNP 中，PTGER3 中的 1 个 SNP 和 4 个 SNP 在 2（nd）队列研究中进行了分析。结果表明，PTGER3 中的 rs7543182 和 rs959 仍然具有作用，尽管在 2（nd）队列研究中没有保留统计学意义。我们的研究结果进一步证明，PTGER3 中的多态性可能在韩国哮喘患者的阿司匹林过敏中发挥重要作用。
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