Liang Xing, Adie Steven G, John Renu, Boppart Stephen A
Department of Electrical and Computer Engineering, Urbana, IL 61801, USA.
Opt Express. 2010 Jun 21;18(13):14183-90. doi: 10.1364/OE.18.014183.
A dynamic spectral-domain optical coherence elastography (OCE) imaging technique is reported. In this technique, audio-frequency compressive vibrations are generated by a piezoelectric stack as external excitation, and strain rates in the sample are calculated and mapped quantitatively using phase-sensitive spectral-domain optical coherence tomography. At different driving frequencies, this technique provides contrast between sample regions with different mechanical properties, and thus is used to mechanically characterize tissue. We present images of a three-layer silicone tissue phantom and rat tumor tissue ex vivo, based on quantitative strain rate. Both acquisition speed and processing speed are improved dramatically compared with previous OCE imaging techniques. With high resolution, high acquisition speed, and the ability to characterize the mechanical properties of tissue, this OCE technique has potential use in non-destructive volumetric imaging and clinical applications.
报道了一种动态光谱域光学相干弹性成像（OCE）技术。在该技术中，压电堆栈产生音频压缩振动作为外部激励，并使用相敏光谱域光学相干断层扫描定量计算和映射样品中的应变率。在不同的驱动频率下，该技术可在具有不同机械性能的样品区域之间提供对比度，从而用于对组织进行机械特性表征。我们基于定量应变率展示了三层硅胶组织模型和大鼠肿瘤组织的离体图像。与先前的OCE成像技术相比，采集速度和处理速度都有了显著提高。这种OCE技术具有高分辨率、高采集速度以及表征组织机械性能的能力，在无损体积成像和临床应用中具有潜在用途。
