Malde Sachin, Wilson Ajay
Department of Urology, Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT, UK.
Patient Saf Surg. 2010 Jun 30;4(1):10. doi: 10.1186/1754-9493-4-10.
The association of the anti-anginal drug nicorandil with oral and anal ulceration is becoming more widely recognised, but there are no reports of isolated nicorandil-induced rectal ulceration. Awareness of this condition is poor, and patients often undergo unnecessary surgery for a condition which resolves on stopping the medication.We report a case of nicorandil-induced rectal ulceration causing rectal bleeding. The patient was spared surgery after awareness of the link with this drug.This diagnosis should be considered in patients with unexplained gastrointestinal ulceration after exclusion of serious underlying causes. We hope this report will increase awareness amongst physicians and surgeons of this reversible condition.
抗心绞痛药物尼可地尔与口腔和肛门溃疡的关联正得到越来越广泛的认识，但尚无关于孤立的尼可地尔诱发直肠溃疡的报道。对此病症的认识不足，患者常因停药后病情缓解的病症而接受不必要的手术。我们报告一例尼可地尔诱发直肠溃疡导致直肠出血的病例。在认识到该药物与病症的关联后，患者避免了手术。排除严重潜在病因后，对于不明原因胃肠道溃疡的患者应考虑这一诊断。我们希望本报告能提高内科医生和外科医生对这种可逆病症的认识。
