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Defining the probability that a cell therapy will produce a malignancy.

作者信息

Prockop Darwin J

出版信息

Mol Ther. 2010 Jul;18(7):1249-50. doi: 10.1038/mt.2010.99.

Abstract
摘要

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本文引用的文献

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Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells.
Exp Cell Res. 2010 May 15;316(9):1648-50. doi: 10.1016/j.yexcr.2010.02.016. Epub 2010 Feb 18.
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Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.
Cancer Res. 2009 Jul 1;69(13):5331-9. doi: 10.1158/0008-5472.CAN-08-4630. Epub 2009 Jun 9.
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Persistent use of "false" cell lines.
Int J Cancer. 2008 Jan 1;122(1):1-4. doi: 10.1002/ijc.23233.
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Sarcoma derived from cultured mesenchymal stem cells.
Stem Cells. 2007 Feb;25(2):371-9. doi: 10.1634/stemcells.2005-0620. Epub 2006 Oct 12.
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Spontaneous human adult stem cell transformation.
Cancer Res. 2005 Apr 15;65(8):3035-9. doi: 10.1158/0008-5472.CAN-04-4194.
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Multistage carcinogenesis in cell culture.
Dev Biol (Basel). 2001;106:61-6; discussion 67, 143-60.

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