新型 S100A7（银屑病素）/S100A15（koebnerisin）亚家族：高度同源但在调控和功能上存在差异。
Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.
机构信息
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
出版信息
Amino Acids. 2011 Oct;41(4):789-96. doi: 10.1007/s00726-010-0666-4. Epub 2010 Jul 2.
Abstract
S100A7 (psoriasin) and S100A15 (koebnerisin) were first identified in inflamed psoriatic skin. They are of major interest because of their putative functional roles in innate immunity, epidermal cell maturation, and epithelial tumorigenesis. Human S100A7 and S100A15 have lately evolved by gene duplications within the epidermal differentiation complex (chromosome 1q21) during primate evolution forming a novel S100 subfamily. Therefore, S100A7 and S100A15 are almost identical in sequence (>90%) and are difficult to discriminate. Despite their high homology, S100A7 and S100A15 are distinct in tissue distribution, regulation, and function, and thus, exemplary for the diversity within the S100 family. Their different properties are compelling reasons to discriminate S100A7 (psoriasin) and S100A15 (koebnerisin) in epithelial homeostasis, inflammation, and cancer.
摘要
S100A7（银屑病相关丝氨酸蛋白酶 7）和 S100A15（表皮角蛋白 15）最初在炎症性银屑病皮肤中被发现。它们之所以受到关注，是因为它们在先天免疫、表皮细胞成熟和上皮肿瘤发生中具有潜在的功能作用。人类 S100A7 和 S100A15 是在灵长类动物进化过程中，通过表皮分化复合物（染色体 1q21）内的基因复制而最近进化形成的一个新的 S100 亚家族。因此，S100A7 和 S100A15 在序列上几乎完全相同（>90%），难以区分。尽管它们具有高度同源性，但 S100A7 和 S100A15 在组织分布、调节和功能上存在差异，因此是 S100 家族多样性的典型代表。它们的不同特性是区分 S100A7（银屑病相关丝氨酸蛋白酶 7）和 S100A15（表皮角蛋白 15）在上皮稳态、炎症和癌症中的重要原因。
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