Wolf Ronald, Voscopoulos Christopher, Winston Jason, Dharamsi Alif, Goldsmith Paul, Gunsior Michele, Vonderhaar Barbara K, Olson Melanie, Watson Peter H, Yuspa Stuart H
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4255, USA.
Cancer Lett. 2009 May 8;277(1):101-7. doi: 10.1016/j.canlet.2008.11.032. Epub 2009 Jan 10.
Human S100A7 (psoriasin) is considered a marker for specific stages of breast cancer. hS100A15 is almost identical to hS100A7 and difficult to discriminate. We developed specific probes to distinguish hS100A7 and hS100A15, and demonstrate their differential distribution in normal breast tissue. Further, hS100A7 and S100A15 transcripts are elevated in ER/PR negative breast cancers, but hS100A15 protein is detected in all cancer specimens while hS100A7 protein is sporadically expressed. The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers.
人S100A7（牛皮癣素）被认为是乳腺癌特定阶段的标志物。hS100A15与hS100A7几乎相同，难以区分。我们开发了特异性探针来区分hS100A7和hS100A15，并证明了它们在正常乳腺组织中的差异分布。此外，hS100A7和S100A15转录本在雌激素受体/孕激素受体（ER/PR）阴性乳腺癌中升高，但在所有癌症标本中均检测到hS100A15蛋白，而hS100A7蛋白则呈散发性表达。hS100A7和hS100A15的差异调节、表达和分布以及它们已报道的不同功能，是在正常乳腺和乳腺癌中区分这些蛋白质的令人信服的理由。
