Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Am Heart J. 2010 Jul;160(1):139-44. doi: 10.1016/j.ahj.2010.03.038.
Advances in heart failure (HF) treatments have prolonged survival, but more patients die of HF than of any type of cancer. Little is known about the current practice in end-of-life (EOL) care in HF.
Two EOL cohorts (HF and cancer) were identified using Medicare data linked with pharmacy and cancer registry data. We assessed use of hospice, opiates, and acute care services (hospitalizations, emergency department [ED] visits, intensive care unit [ICU] admissions, and death in acute care). Time trends and predictors of use were assessed using multivariate regression including demographics and cardiovascular and noncardiovasuclar comorbidities.
Among 5,836 HF patients with median age of 85, 77% female and 4% black, 20% were referred to hospice compared to 51% of 7,565 cancer patients. A modest rise in hospice use over time was parallel in the 2 groups. Twenty-two percent of HF patients filled opiate prescriptions during 60 days before death compared to 46% of cancer patients. Use of acute care services in the 30 days before death was higher for HF (64% vs 39% for ED visits, 60% vs 45% for hospitalizations, and 19% vs 7% for ICU admission). More HF patients died during acute hospitalizations than cancer patients (39% vs 21%).
Patients dying of HF were less likely to be supported by hospice and opiates but more likely to die in hospitals than patients with cancer. Our study suggests that opportunities may exist to improve hospice and opiate use in HF patients.
心力衰竭(HF)治疗的进步延长了患者的生存时间,但死于 HF 的患者比死于任何类型癌症的患者都多。目前 HF 患者在生命末期(EOL)的护理实践知之甚少。
使用医疗保险数据与药房和癌症登记数据进行链接,确定了两个 EOL 队列(HF 和癌症)。我们评估了临终关怀、阿片类药物和急性护理服务(住院、急诊就诊、重症监护病房(ICU)入院和急性护理中的死亡)的使用情况。使用包括人口统计学和心血管及非心血管合并症在内的多变量回归评估使用情况的时间趋势和预测因素。
在 5836 名 HF 患者中,中位数年龄为 85 岁,77%为女性,4%为黑人,20%的患者被转诊至临终关怀,而 7565 名癌症患者中有 51%被转诊至临终关怀。两组患者的临终关怀使用率都呈适度上升趋势。在死亡前 60 天,22%的 HF 患者开了阿片类药物处方,而癌症患者的这一比例为 46%。在死亡前 30 天,HF 患者使用急性护理服务的比例更高(ED 就诊 64%比 39%,住院 60%比 45%,ICU 入院 19%比 7%)。HF 患者在急性住院期间死亡的比例高于癌症患者(39%比 21%)。
死于 HF 的患者接受临终关怀和阿片类药物的可能性较小,但更有可能在医院死亡,而不是癌症患者。我们的研究表明,HF 患者在临终关怀和阿片类药物的使用方面可能有机会得到改善。