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K Ergünay, M B Saygan, S Aydoğan, N Litzba, B Sener, S Lederer, M Niedrig, G Hasçelik, D Us
Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Zoonoses Public Health. 2011 May;58(3):220-7. doi: 10.1111/j.1863-2378.2010.01342.x.
Tick-borne encephalitis virus (TBEV) is the aetiological agent of tick-borne encephalitis (TBE), a potentially fatal central nervous system infection of humans. TBE is endemic in many areas of Europe and Asia; however, very scarce data on TBEV activity are available from Turkey. We aimed to identify TBEV exposure in healthy blood donors and the impact of TBEV in central nervous system infections in Central/Northern Anatolia. Two-thousand four hundred and fifty four sera, collected from blood donors at Ankara, Konya, Eskişehir and Zonguldak branches of the Turkish Red Crescent Middle Anatolia Regional Blood Center, were analysed for TBEV serosurveillance. Paired serum and cerebrospinal fluid samples from 108 patients with the diagnosis of aseptic meningitis/encephalitis of unknown aetiology were also evaluated to identify TBE and neuroborreliosis cases. Commercial enzyme-linked immunosorbent assays and indirect immunofluorescence tests were employed for antibody detection. Forty-seven donor samples (1.9%) were reactive for TBEV IgG. In 25 persons with IgG reactivity (53.1%), risk factors for tick-borne infections were revealed. One sample from Zonguldak province (1/198; 0.5%) in the Black Sea region of Turkey was confirmed to possess neutralizing antibodies via plaque reduction neutralization test. TBEV IgM was detected in 9.2% (8/108) of the patients. IgM was accompanied by IgG reactivity in two persons where, in one, recent history of a tick bite was also identified. Intrathecal antibody production for TBEV could not be demonstrated. No evidence for Borrelia infections could be found. Confirmed exposure to TBEV and/or an antigenically similar tick-borne flavivirus is documented for the first time in blood donors in Zonguldak in Northern Anatolia. Probable cases of TBE have also been identified from Central Anatolia. The epidemiology of TBEV activity in Turkey needs to be assessed and benefits of vaccination for general population, risk groups or travellers must be considered.
蜱传脑炎病毒（TBEV）是蜱传脑炎（TBE）的病原体，TBE 是一种潜在致命的人类中枢神经系统感染。TBE 在欧洲和亚洲的许多地区流行；然而，土耳其关于 TBEV 活动的数据非常稀缺。我们旨在确定健康献血者中 TBEV 的暴露情况，以及 TBEV 在中/北安纳托利亚中枢神经系统感染中的影响。我们分析了来自土耳其红新月会中安纳托利亚地区血液中心安卡拉、科尼亚、埃斯基谢希尔和宗古尔达克分部的 2454 份献血者血清，以进行 TBEV 血清监测。还评估了 108 例无菌性脑膜炎/脑炎病因不明患者的配对血清和脑脊液样本，以确定 TBE 和神经莱姆病病例。采用商业酶联免疫吸附试验和间接免疫荧光试验检测抗体。47 份供体样本（1.9%）对 TBEV IgG 呈反应性。在 25 名 IgG 反应性患者（53.1%）中，发现了蜱传感染的危险因素。土耳其黑海地区宗古尔达克省的一份样本（1/198；0.5%）通过蚀斑减少中和试验证实具有中和抗体。在 108 例患者中，9.2%（8/108）检测到 TBEV IgM。IgM 在 2 名患者中伴有 IgG 反应性，其中 1 名患者还确定了近期蜱叮咬史。未能证明 TBEV 抗体的鞘内产生。未发现伯氏疏螺旋体感染的证据。首次在北安纳托利亚宗古尔达克的献血者中记录了 TBEV 的确认暴露和/或类似抗原的蜱传黄病毒。还从中安纳托利亚确定了 TBE 的可能病例。需要评估土耳其 TBEV 活动的流行病学，必须考虑为普通人群、风险群体或旅行者接种疫苗的益处。
