Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea.
Arch Pharm Res. 2010 Jun;33(6):853-61. doi: 10.1007/s12272-010-0607-5. Epub 2010 Jul 6.
Phellinus linteus, which is a traditional medicinal mushroom used in Asian countries for the treatment of various diseases, has attracted a lot of attention due to its antioxidant, anti-inflammatory, anti-mutagenicity, and cell-mediated immunity properties in addition to its ability to inhibit tumor growth and metastasis. However, the antidiabetic efficacy of P. linteus has not yet been examined. In this study, hispidin from P. linteus exhibited quenching effects against DPPH radicals, superoxide radicals, and hydrogen peroxide in a dose-dependent manner. Intracellular reactive oxygen species scavenging activity of hispidin was approximately 55% at a concentration of 30 microM. In addition, hispidin was shown to inhibit hydrogen peroxide-induced apoptosis and increased insulin secretion in hydrogen peroxide-treated cells. These combined results indicate that hispidin may act as an antidiabetic and that this property occurs through preventing beta-cells from the toxic action of reactive oxygen species in diabetes.
木蹄层孔菌，一种在亚洲国家被用于治疗各种疾病的传统药用蘑菇，因其具有抗氧化、抗炎、抗诱变和细胞介导的免疫特性，以及抑制肿瘤生长和转移的能力，引起了广泛关注。然而，木蹄层孔菌的降血糖功效尚未得到检验。在这项研究中，木蹄层孔菌中的疣柄多孔菌素表现出对 DPPH 自由基、超氧自由基和过氧化氢的剂量依赖性淬灭作用。在 30μM 的浓度下，疣柄多孔菌素对细胞内活性氧的清除活性约为 55%。此外，疣柄多孔菌素还能抑制过氧化氢诱导的细胞凋亡，并增加过氧化氢处理细胞中的胰岛素分泌。这些综合结果表明，疣柄多孔菌素可能具有降血糖作用，其作用机制可能是通过防止β细胞受到糖尿病中活性氧的毒性作用。
