Ohashi M, Onaka K, Nawata H, Minamino N, Matsuo H
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
Fukuoka Igaku Zasshi. 1991 Apr;82(4):131-5.
We demonstrated that a novel natriuretic hormone, brain natriuretic peptide, modestly inhibited the production of cortisol and aldosterone stimulated by ACTH in cultured bovine adrenocortical cells. Moreover, the presence of brain natriuretic peptide was demonstrated in bovine adrenal medulla, suggesting that it may modulate adrenocortical steroidogenesis. Using a specific radioimmunoassay (RIA) for brain natriuretic peptide-26, we confirmed that human cardiac atrial tissues elaborated a considerable amount of brain natriuretic peptide-26-like immunoreactivity (1.00 +/- 0.17 micrograms/g wet weight tissue, n = 3). Its molecular form was similar to that of brain natriuretic peptide-32 and possibly, to gamma-brain natriuretic peptide. However, any immunoreactivity of brain natriuretic peptide could not be detected in human pheochromocytoma tissues and some tissues of the human central nervous system. These observations suggest that brain natriuretic peptide dose not function as a neuropeptide but that it may be a cardiac natriuretic hormone important in human physiology, involved in the balance of water and electrolytes.
我们证明了一种新型利钠激素——脑钠肽，在培养的牛肾上腺皮质细胞中可适度抑制促肾上腺皮质激素（ACTH）刺激的皮质醇和醛固酮生成。此外，在牛肾上腺髓质中证实存在脑钠肽，这表明它可能调节肾上腺皮质类固醇生成。通过使用针对脑钠肽 - 26的特异性放射免疫分析（RIA），我们证实人类心脏心房组织产生了相当数量的脑钠肽 - 26样免疫反应性物质（1.00±0.17微克/克湿重组织，n = 3）。其分子形式与脑钠肽 - 32相似，可能还与γ - 脑钠肽相似。然而，在人类嗜铬细胞瘤组织和人类中枢神经系统的一些组织中未检测到脑钠肽的任何免疫反应性。这些观察结果表明，脑钠肽并非作为神经肽发挥作用，而是可能作为一种在人体生理学中重要的心脏利钠激素，参与水和电解质平衡。
