Tanaka R, Sekiguchi K, Ueki K, Gilden D H, Koprowski H
Acta Neuropathol. 1978 Mar 15;41(3):235-9. doi: 10.1007/BF00690442.
The cytomorphology and cytogenesis of BK virus-transformed hamster brain cells (HBBK cells) were studied. HBBK cells with indistinct processes showed a tendency to epithelial arrangement as well as characteristics of malignant tumor cells in vitro, and developed long, delicate processes when cell growth was suppressed. Glial fibrillary acidic protein was demonstrated by immunofluorescence in the cytoplasm of almost all HBBK cells. The tumors arising in hamsters after subcutaneous inoculation of HBBK cells were classified as poorly differentiated gliomas. These findings suggest that selective transformation of glial cells in hamster brain cells by BK virus occurred.
对BK病毒转化的仓鼠脑细胞（HBBK细胞）的细胞形态学和细胞发生进行了研究。HBBK细胞的突起不明显，在体外显示出上皮排列的倾向以及恶性肿瘤细胞的特征，当细胞生长受到抑制时会形成长而纤细的突起。几乎所有HBBK细胞的细胞质中通过免疫荧光检测到胶质纤维酸性蛋白。皮下接种HBBK细胞后在仓鼠体内产生的肿瘤被归类为低分化胶质瘤。这些发现表明BK病毒在仓鼠脑细胞中发生了胶质细胞的选择性转化。
