BK病毒导致仓鼠肾细胞的恶性转化。
Malignant transformation of hamster kidney cells by BK virus.
作者信息
Portolani M, Barbanti-Brodano G, Placa M L
出版信息
J Virol. 1975 Feb;15(2):420-2. doi: 10.1128/JVI.15.2.420-422.1975.
Abstract
Primary hamster kidney cells were transformed by BK virus, a new human papovavirus. Transformed (HKBK) cell produced BK virus T antigen and induced tumors in hamsters that developed antibodies to BK virus T antigen. BK virus was rescued from HKBK cells by Sendai virus-assisted fusion with permissive cells. One out of six cell lines derived from HKBK cell-induced tumors showed the same characteristics as HKBK cells.
摘要
原代仓鼠肾细胞被一种新的人乳头多瘤空泡病毒——BK病毒转化。转化后的（HKBK）细胞产生BK病毒T抗原，并在仓鼠体内诱发肿瘤，这些仓鼠产生了针对BK病毒T抗原的抗体。通过仙台病毒辅助与允许性细胞融合，从HKBK细胞中拯救出了BK病毒。从HKBK细胞诱导的肿瘤中衍生出的六个细胞系中有一个表现出与HKBK细胞相同的特征。
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