人乳头多瘤空泡病毒Bk在体外诱导仓鼠脑细胞恶性转化
Malignant transformation of hamster brain cells in vitro by human papovavirus Bk.
作者信息
Tanaka R, Koprowski H, Iwasaki Y
出版信息
J Natl Cancer Inst. 1976 Mar;56(3):671-3. doi: 10.1093/jnci/56.3.671.
PMID:176404
Abstract
Human papovavirus BK caused the malignant transformation in vitro of brain cells prepared from newborn hamsters. The transformed cells produced BK virus T antigen and grew as tumors after sc inoculation ito hamsters that developed antibodies to BK virus T antigen. The histopathology of the tumors revealed an undifferentiated glioma.
摘要
人乳头多瘤空泡病毒BK可使新生仓鼠制备的脑细胞在体外发生恶性转化。转化细胞产生BK病毒T抗原，接种到对BK病毒T抗原产生抗体的仓鼠皮下后会形成肿瘤生长。肿瘤的组织病理学显示为未分化胶质瘤。
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