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群体结构对法医学中DNA指纹分析的影响。

Effects of population structure on DNA fingerprint analysis in forensic science.

作者信息

Nichols R A, Balding D J

机构信息

School of Biological Sciences, Queen Mary and Westfield College, University of London, UK.

出版信息

Heredity (Edinb). 1991 Apr;66 ( Pt 2):297-302. doi: 10.1038/hdy.1991.37.

Abstract

DNA fingerprints are used in forensic sciences to identify individuals. However, current analyses could underestimate the probability of two individuals sharing the same profile because the effect of population structure is not incorporated. An alternative analysis is proposed to take into account population stratification. The analysis uses studies of inbreeding in human populations to obtain an empirical upper bound on the magnitude of the effect.

摘要

DNA指纹在法医学中用于识别个体。然而,目前的分析可能会低估两个个体具有相同图谱的概率,因为未纳入群体结构的影响。本文提出了一种替代分析方法,以考虑群体分层。该分析利用对人类群体近亲繁殖的研究来获得效应大小的经验上限。

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