Momose Haruka, Mizukami Takuo, Ochiai Masaki, Hamaguchi Isao, Yamaguchi Kazunari
Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan.
J Biomed Biotechnol. 2010;2010:361841. doi: 10.1155/2010/361841. Epub 2010 Jun 13.
For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using experimental biology and genome science provide an important means of assessment for vaccine toxicity.
在过去的50年里，质量控制和安全性测试一直被用于评估疫苗的安全性。然而，传统的动物安全性测试在几个方面需要改进。例如，所用实验动物的数量需要减少，测试周期需要缩短。因此，有必要开发一种新的疫苗评估系统。在这篇综述中，我们表明基因表达模式与接种疫苗的大鼠的生物学反应密切相关。我们利用实验生物学和基因组科学的研究结果及方法为疫苗毒性评估提供了一种重要手段。
