PTX3 在侵袭性曲霉菌病大鼠模型中的疗效。
Efficacy of PTX3 in a rat model of invasive aspergillosis.
机构信息
R&D Department, Sigma-Tau SpA00040 Pomezia, RM, Italy.
出版信息
Antimicrob Agents Chemother. 2010 Oct;54(10):4513-5. doi: 10.1128/AAC.00674-10. Epub 2010 Jul 12.
Abstract
Pentraxin 3 (PTX3) is an acute-phase glycoprotein with a nonredundant function in the host resistance to Aspergillus fumigatus. PTX3 activity was evaluated against pulmonary aspergillosis in rats immunosuppressed with cortisone acetate. PTX3 enhanced the survival rate and reduced the lung fungal burden of infected rats in both therapeutic and prophylactic modalities. Thus, we extended the protective activity of PTX3 in pulmonary aspergillosis to corticosteroid-induced immunodeficiency, which is a relevant clinical condition in graft-versus-host disease and in solid organ transplant.
摘要
五聚素 3（PTX3）是一种急性相糖蛋白，在宿主抵抗烟曲霉中具有不可替代的功能。评估了 PTX3 对醋酸可的松免疫抑制大鼠肺部曲霉病的作用。PTX3 在治疗和预防两种方式下均提高了感染大鼠的存活率并降低了肺部真菌负荷。因此，我们将 PTX3 在肺部曲霉病中的保护作用扩展到了皮质类固醇诱导的免疫缺陷，这在移植物抗宿主病和实体器官移植中是一种相关的临床情况。
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