Department of Surgery, Jeroen Bosch Hospital, Nieuwstraat 54, 5211's-Hertogenbosch, The Netherlands.
J Oncol. 2010;2010:865908. doi: 10.1155/2010/865908. Epub 2010 Jun 13.
Introduction. Colonic cancer is one of the most commonly diagnosed malignancies and most often occurs in patients aged 65 years or older. Aim. To evaluate the outcome of colonic surgery in the elderly in our hospital and to compare five-year survival rates between the younger and elderly patients. Methods. 207 consecutive patients underwent surgery for colon cancer. Patients were separated in patients younger than 75 and older than 75 years. Results. Elderly patients presented significantly more (P < .05) as a surgical emergency, had a longer duration of admission and were more often admitted to the ICU (P < .01). Also, elderly patients had significant more co-morbidities, especially cardiovascular pathology (P < .01). Post-operative complications were seen more often in the elderly, although no significant difference was seen in anastomotic leakage. The five-year survival rate in the younger group was 62% compared with 36% in the elderly (P < .05). DFS was 61% in the younger patients compared with 32% in the elderly (P < .05). Conclusion. Curative resection of colonic carcinoma in the elderly is well tolerated and age alone should not be an indication for less aggressive therapy. However, the type and number of co-morbidities influence post-operative mortality and morbidity.
介绍。结肠癌是最常见的诊断恶性肿瘤之一，最常发生在 65 岁或以上的患者中。目的。评估我们医院老年患者结肠手术的结果，并比较年轻患者和老年患者的五年生存率。方法。207 例连续接受结肠癌手术的患者。患者分为 75 岁以下和 75 岁以上两组。结果。老年患者更常见（P<.05）作为紧急手术，住院时间更长，更常被收入 ICU（P<.01）。此外，老年患者有更多的合并症，特别是心血管疾病（P<.01）。老年患者术后并发症更为常见，尽管吻合口漏的发生率无显著差异。年轻组的五年生存率为 62%，而老年组为 36%（P<.05）。年轻患者的DFS 为 61%，而老年患者为 32%（P<.05）。结论。老年患者结肠癌的根治性切除是可以耐受的，单纯年龄不应成为采用侵袭性较小治疗的指征。然而，合并症的类型和数量影响术后死亡率和发病率。
