Freitas A A, Rocha B, Coutinho A A
Immunol Rev. 1986 Jun;91:5-37. doi: 10.1111/j.1600-065x.1986.tb01482.x.
In a normal dynamic equilibrium, at least half of the peripheral T-cell pool is constituted by lymphocytes which have divided 24-48 h previously, and are therefore rapidly renewed. The renewal of peripheral T cells occurs partly by influx of cells from the thymus and, more importantly, by cell division at the periphery. The cyclic pattern of decay observed for T cells after HU treatment suggests the presence of progenitor-descendent relationships within the peripheral T-cell pool. Peripheral progenitors must contain both cycling and non-cycling cells to account for cell recovery after HU administration in ATx mice. T-cell production at the periphery involves both organized (spleen or lymph nodes) as well as non-organized lymphoid tissue (GALT). The latter may in fact provide the major contribution. Expansion of mature T lymphocytes contributes to clonal persistence at the periphery and to the choice of T-cell repertoires. The importance of post-thymic selection of T-cell repertoires is suggested by the considerable expansion potential revealed by peripheral T cells.
在正常的动态平衡中，至少一半的外周T细胞池由24 - 48小时前已分裂的淋巴细胞构成，因此能迅速更新。外周T细胞的更新部分通过胸腺细胞的流入，更重要的是通过外周的细胞分裂。HU处理后T细胞出现的周期性衰减模式表明外周T细胞池中存在祖细胞 - 子代关系。外周祖细胞必须同时包含循环细胞和非循环细胞，以解释ATx小鼠给予HU后细胞的恢复情况。外周T细胞的产生涉及有组织的（脾脏或淋巴结）以及无组织的淋巴组织（肠道相关淋巴组织）。事实上，后者可能起主要作用。成熟T淋巴细胞的扩增有助于外周克隆的持续存在以及T细胞库的选择。外周T细胞显示出的相当大的扩增潜力表明胸腺后T细胞库选择的重要性。
