Yam Mun Fei, Ang Lee Fung, Ameer Omar Ziad, Salman Ibrahim Muhammad, Aziz Hesham Abdul, Asmawi Mohd Zaini
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia.
J Acupunct Meridian Stud. 2009 Dec;2(4):280-7. doi: 10.1016/S2005-2901(09)60069-8.
Elephantopus tomentosus is widely used in Asia, especially in Malaysia, for the treatment of pain and inflammation. In the present study, the analgesic and anti-inflammatory effects of a 95% ethanol extract of E. tomentosus were investigated in different experimental models. In the anti-inflammation study, 1000 mg/kg of extract significantly reduced carrageenan-induced hind paw edema (p < 0.05) and inhibited abdominal permeability compared with control (p < 0.01). The analgesic activity was assayed in several experimental models in mice: (1) hot plate, (2) tail flick, (3) writhing test; and rats: carrageenan-induced hyperalgesia pain threshold test. However, at the doses tested, no significant activity was found in the hot plate test and the tail flick test. E. tomentosus ethanol extract at 1000 mg/kg significantly (p < 0.05) increased hyperalgesia pain threshold and inhibited writhing activity. The results suggest that E. tomentosus ethanol extract at 1000 mg/kg dose is effective in anti-inflammatory and non-steroidal anti-inflammatory drug type anti-nociception activities.
绒毛地胆草在亚洲广泛应用，尤其是在马来西亚，用于治疗疼痛和炎症。在本研究中，在不同实验模型中研究了绒毛地胆草95%乙醇提取物的镇痛和抗炎作用。在抗炎研究中，与对照组相比，1000mg/kg提取物显著减轻了角叉菜胶诱导的后爪水肿（p<0.05）并抑制了腹部通透性（p<0.01）。在小鼠的多个实验模型中测定了镇痛活性：（1）热板法，（2）甩尾法，（3）扭体试验；以及在大鼠中：角叉菜胶诱导的痛觉过敏疼痛阈值试验。然而，在所测试的剂量下，在热板试验和甩尾试验中未发现显著活性。1000mg/kg的绒毛地胆草乙醇提取物显著（p<0.05）提高了痛觉过敏疼痛阈值并抑制了扭体活性。结果表明，1000mg/kg剂量的绒毛地胆草乙醇提取物在抗炎和非甾体抗炎药类型的抗伤害感受活性方面是有效的。
