Hamoudi Meriem, Amroun Djouher, Baghiani Abderrahmane, Khennouf Seddik, Dahamna Saliha
Ferhat Abbas Setif 1 University Faculty of Natural and Life Sciences, Laboratory of Phytotherapy Applied to Chronic Diseases, Setif, Algeria
Ferhat Abbas Setif 1 University Faculty of Natural and Life Sciences, Laboratory of Applied Biochemistry, Setif, Algeria
Turk J Pharm Sci. 2021 Oct 28;18(5):574-580. doi: 10.4274/tjps.galenos.2021.24571.
(Ephedraceae) presents a wide range of biological activities. It is used to treat respiratory problems and hepatic pathologies in traditional medicine. The aim of this study is to evaluate the antioxidant, and anti-inflammatory and analgesic properties of two hydro-alcoholic extracts of in mice.
The antioxidant capacity of hydro-methanolic (HM) and hydro-ethanolic (HE) extracts of was evaluated via assays of their superoxide radical scavenging capacity and ferrous ion chelating activity. The anti-inflammatory activity of the extracts (5, 10, and 20 mg/kg) was also determined using the bovine serum albumin denaturation test. Croton oil-induced ear edema was then employed to evaluate the anti-inflammatory effect of the extracts (200 and 400 mg/kg). Finally, the analgesic activity of the extracts (200 and 400 mg/kg) was determined by the acetic acid-induced torsion test.
The hydro-alcoholic extracts of present significant antioxidant activity. The HE and HM could inhibit protein denaturation by 82.99%±20.21% and 56.25%±2.12%, respectively. The extracts (HM and HE) also show strong anti-inflammatory effects and could reduce ear edema by 70.37%±2.00% and 72.22%±1.94%, respectively. The HM extract (72.51%±2.43%) demonstrates greater pain inhibitory effects than HE (70.76%±2.58%).
The hydro-alcoholic extracts of E. nebrodensis produce antioxidant, anti-inflammatory, and analgesic effects. These results confirm the traditional use of the herb in the treatment of various diseases.
麻黄科植物具有广泛的生物活性。在传统医学中，它被用于治疗呼吸系统疾病和肝脏疾病。本研究的目的是评估麻黄科植物两种水醇提取物在小鼠体内的抗氧化、抗炎和镇痛特性。
通过测定水甲醇（HM）和水乙醇（HE）提取物的超氧自由基清除能力和亚铁离子螯合活性来评估其抗氧化能力。还使用牛血清白蛋白变性试验测定提取物（5、10和20mg/kg）的抗炎活性。然后采用巴豆油诱导的耳肿胀来评估提取物（200和400mg/kg）的抗炎作用。最后，通过醋酸诱导的扭体试验测定提取物（200和400mg/kg）的镇痛活性。
麻黄科植物的水醇提取物具有显著的抗氧化活性。HE和HM分别能抑制蛋白质变性82.99%±20.21%和56.25%±2.12%。提取物（HM和HE）也显示出较强的抗炎作用，分别能使耳肿胀减轻70.37%±2.00%和72.22%±1.94%。HM提取物（72.51%±2.43%）的镇痛效果比HE（70.76%±2.58%）更强。
内华达麻黄的水醇提取物具有抗氧化、抗炎和镇痛作用。这些结果证实了该草药在治疗各种疾病方面的传统用途。
