Department of Oral Medicine/Dental Research Center, Dentistry School, Tehran University of Medical Sciences, Tehran, Iran.
Aging Clin Exp Res. 2013 May;25(2):147-51. doi: 10.1007/s40520-013-0023-z. Epub 2013 Mar 27.
The aim of this study was to compare unstimulated whole saliva 25-hydroxycholecalciferol (25(OH)D) in menopausal women with and without oral dryness (OD) feeling, and evaluate the relationship between saliva 25(OH)D and severity of OD feeling.
A case-control study was carried out on 70 selected menopausal women aged 41-77 years with or without OD feeling (35 as case and 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Unstimulated saliva samples were obtained by expectoration. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The saliva 25(OH)D concentration was measured by ELISA. Statistical analysis of Student's t test and Spearman correlation was used.
The mean saliva 25(OH)D level was significantly higher in the case group (897.1 ± 128.9 pg/ml), compared with control (156.7 ± 43.4 pg/ml; P < 0.05). XI score correlated significantly with saliva 25(OH)D concentration (r = 0.457, P < 0.001).
It seems that the level of salivary 25(OH)D concentration may be higher in menopausal women with OD feeling than in the control group, and there is a positive correlation between OD feeling severity and unstimulated whole saliva 25(OH)D.
本研究旨在比较绝经后伴有或不伴有口干感觉（OD）的女性的未刺激全唾液 25-羟胆钙化醇（25（OH）D），并评估唾液 25（OH）D 与 OD 感觉严重程度之间的关系。
在德黑兰医科大学口腔医学诊所对 70 名年龄在 41-77 岁之间的绝经后女性进行了一项病例对照研究，这些女性伴有或不伴有 OD 感觉（35 例为病例组，35 例为对照组）。通过咳痰获得未刺激唾液样本。口干量表（XI）评分作为 OD 感觉严重程度的指标。使用 ELISA 测量唾液 25（OH）D 浓度。采用 Student's t 检验和 Spearman 相关分析进行统计分析。
与对照组（156.7 ± 43.4 pg/ml；P < 0.05）相比，病例组的平均唾液 25（OH）D 水平明显更高（897.1 ± 128.9 pg/ml）。XI 评分与唾液 25（OH）D 浓度呈显著正相关（r = 0.457，P < 0.001）。
绝经后伴有 OD 感觉的女性唾液 25（OH）D 浓度可能高于对照组，OD 感觉严重程度与未刺激全唾液 25（OH）D 呈正相关。
