Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Gynecol Endocrinol. 2012 Mar;28(3):199-202. doi: 10.3109/09513590.2011.593668. Epub 2011 Aug 8.
One of the most common oral manifestations of menopause is xerostomia. As gingival tissue is sensitive to changes in the female sex steroids; the aim of this study was to evaluate the relationship between saliva 17β-estradiol and severity of xerostomia. A case-control study was carried out in 64 selected menopausal women aged 42-75 years with or without xerostomia (32 as case and 32 as control) conducted at the Clinic of Oral Medicine, Tehran university of medical sciences. Xerostomia inventory (XI) score was used as an index of xerostomia severity. The saliva 17β-estradiol was measured by an enzyme immunoassay kit. The mean unstimulated saliva flow rate and concentration of 17β-estradiol were significantly lower in case than control. There were significant negative correlation between XI score and unstimulated whole saliva flow rate and also concentration of 17β-estradiol in menopausal women. It seems that there is a negative correlation between xerostomia severity and saliva 17β-estradiol in menopausal women.
绝经后最常见的口腔表现之一是口干症。由于牙龈组织对女性性激素的变化敏感；本研究旨在评估唾液 17β-雌二醇与口干严重程度之间的关系。在德黑兰医科大学口腔医学诊所进行了一项病例对照研究，共纳入 64 名 42-75 岁的绝经后妇女，其中 32 名有口干症（病例组），32 名无口干症（对照组）。口干症量表（XI）评分作为口干严重程度的指标。采用酶联免疫试剂盒检测唾液 17β-雌二醇。与对照组相比，病例组的未刺激唾液流率和 17β-雌二醇浓度明显降低。绝经后妇女的 XI 评分与未刺激全唾液流率以及 17β-雌二醇浓度呈显著负相关。口干严重程度与唾液 17β-雌二醇之间存在负相关。
