Department of Oral Medicine/Dental Research Center, Dentistry School, Tehran University of Medical Sciences, Iran.
Aust Dent J. 2011 Jun;56(2):171-4. doi: 10.1111/j.1834-7819.2011.01320.x.
Menopause may be associated with some adverse changes, such as oral dryness (OD) feeling. The exact mechanisms that mediate sensation of OD in menopausal women have not been firmly established. The purpose of this study was to assess the relationship of unstimulated whole saliva cortisol level with severity of OD feeling in menopausal women.
A case control study was carried out on 70 selected menopausal women with/without OD feeling, conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences, Iran. The xerostomia inventory (XI) score was used as an index of OD feeling severity. Unstimulated whole saliva cortisol concentration was measured by ELISA. Statistical analysis of student's t-test and Spearman correlation was used.
The mean cortisol concentration of saliva was significantly higher in women with OD feeling than the control. There was significant positive correlation between the XI score and the concentration of unstimulated whole saliva cortisol (r = 0.559, p = 0.025).
Unstimulated whole saliva cortisol is higher in menopausal women with OD feeling than in controls and this correlates with the severity of OD.
绝经可能与一些不良反应有关，如口腔干燥感（OD）。介导绝经妇女 OD 感觉的确切机制尚未确定。本研究旨在评估未刺激全唾液皮质醇水平与绝经妇女 OD 感觉严重程度的关系。
在伊朗德黑兰医科大学口腔医学诊所进行了一项病例对照研究，共纳入 70 名有/无 OD 感觉的绝经妇女。OD 感觉严重程度的指标为口干量表（XI）评分。通过 ELISA 测量未刺激全唾液皮质醇浓度。采用学生 t 检验和斯皮尔曼相关分析进行统计分析。
有 OD 感觉的女性唾液皮质醇浓度明显高于对照组。XI 评分与未刺激全唾液皮质醇浓度呈显著正相关（r = 0.559，p = 0.025）。
有 OD 感觉的绝经妇女未刺激全唾液皮质醇水平高于对照组，且与 OD 严重程度相关。
