Nandkumar Sunita, Desai Madhavi, Butani Manju, Udwadia Z
Senior consultant, P.D. Hinduja National hospital & Medical research centre, Veer savarkar marg, Mahim, MUMBAI-400016, INDIA.
Indian J Anaesth. 2009 Jun;53(3):362-6.
Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by accumulation of amorphous acellular phospholipid material in the lungs. Whole lung lavage is the standard therapy which gives dramatic clinical improvement and offers a long term survival to these patients. A 43-year-old man suffering from PAP presented to casualty with NYHA grade IV dyspnoea with oxygen saturation (SaO(2)) on pulseoximetry 67% on room air and 78% with O(2) 6 L/min. He underwent whole lung lavage under general anaesthesia using one lung ventilation with 37 F left end bronchial double lumen tube. The lung lavage was initially performed for the left lung and for the right lung 4 days later. The patient was discharged home with oxygen saturation of 96 % on room air.
肺泡蛋白沉积症（PAP）是一种罕见的疾病，其特征是肺部出现无定形无细胞磷脂物质的积聚。全肺灌洗是标准治疗方法，可带来显著的临床改善，并为这些患者提供长期生存机会。一名43岁患有PAP的男性因纽约心脏协会（NYHA）IV级呼吸困难就诊于急诊室，在室内空气中经脉搏血氧饱和度测定氧饱和度（SaO₂）为67%，吸氧6升/分钟时为78%。他在全身麻醉下使用37F左支气管端双腔管进行单肺通气，接受了全肺灌洗。最初对左肺进行肺灌洗，4天后对右肺进行灌洗。患者出院时在室内空气中氧饱和度为96%。
