Henry Eyring Center for Cell and Genome Science, University of Utah, Salt Lake City, Utah.
Traffic. 2019 Aug;20(8):543-551. doi: 10.1111/tra.12651. Epub 2019 May 30.
Eisosomes are furrows in the yeast plasma membrane that form a membrane domain with distinct lipid and protein composition. Recent studies highlighted the importance of this domain for the regulation of proton-nutrient symporters. The amino acids and other nutrients, which these transporters deliver to the cytoplasm not only feed into metabolic pathways but also activate the metabolic regulator TORC1. Eisosomes have also been shown to harbor the membrane stress sensors Slm1 and Slm2. Membrane tension caused by hypoosmotic shock results in the redistribution of Slm1/2 from eisosomes to TORC2 which in turn regulates lipid synthesis. Therefore, eisosomes function upstream of both TORC1 and TORC2 regulation.
内凹是酵母质膜上的凹痕，形成具有独特脂质和蛋白质组成的膜域。最近的研究强调了这个区域对质子营养转运体调节的重要性。这些转运体将氨基酸和其他营养物质输送到细胞质中，不仅为代谢途径提供营养，还激活代谢调节剂 TORC1。内凹也被证明含有膜应激传感器 Slm1 和 Slm2。低渗冲击引起的膜张力导致 Slm1/2 从内凹重新分布到 TORC2，进而调节脂质合成。因此，内凹在 TORC1 和 TORC2 的调节上游发挥作用。
