National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892-2670, USA.
J Am Acad Child Adolesc Psychiatry. 2010 Aug;49(8):772-82. doi: 10.1016/j.jaac.2009.12.022. Epub 2010 Apr 9.
To place imaging-genetics research in the context of child psychiatry.
A conceptual overview is provided, followed by discussion of specific research examples.
Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.
Child psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics.
将影像遗传学研究置于儿童精神病学的背景下。
提供了概念概述,然后讨论了具体的研究示例。
描述了将大脑功能与两种特定基因(血清素再摄取转运蛋白和单胺氧化酶)联系起来的影像遗传学研究。然后介绍了影像遗传学中的表型选择工作。
影像遗传学在儿童精神病学中的应用才刚刚开始出现。该方法有望促进对病理生理学和治疗学的理解。