Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Neuroimage. 2014 Feb 1;86:544-53. doi: 10.1016/j.neuroimage.2013.07.064. Epub 2013 Aug 3.
The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1445 adolescents ages 8-21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and the measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development.
费城神经发育队列（PNC）是一个大规模的、由 NIMH 资助的项目，旨在了解大脑成熟如何介导认知发展和精神疾病易感性，并了解遗传如何影响这一过程。作为该研究的一部分，1445 名 8-21 岁的青少年在入组时接受了多模态神经影像学检查。在这里，我们重点介绍了该研究的概念基础、研究设计以及数据集提供的测量方法。我们关注的神经影像学测量包括 T1 加权结构神经影像学、弥散张量成像、动脉自旋标记灌注神经影像学、工作记忆和情绪识别功能成像任务以及功能连接的静息态成像。此外，我们提供了关于最终获得的样本的特征。最后，我们描述了数据共享的机制，这将使 PNC 成为一个免费的公共资源，以推进我们对正常和病理性大脑发育的理解。
