Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Dev Cell. 2010 Jul 20;19(1):13-26. doi: 10.1016/j.devcel.2010.06.013.
Cancer cells can move through tissues in a variety of different ways. In some cases, an epithelial-to-mesenchymal transition enables cancer cells to acquire fibroblast-like migratory properties. However, it is also becoming apparent that some cancer cells move in an amoeboid way similar to leukocytes. This theme will be the focus of the review, where we will discuss the similarities and differences between the mechanisms used by cancer cells and leukocytes to cross parenchymal basement membranes, move through interstitial tissue, and enter and exit the vasculature. Further, we propose that the ability to switch between different migratory mechanisms is critical for cells to relocate from one tissue to another.
癌细胞可以通过多种不同的方式在组织中移动。在某些情况下，上皮-间充质转化使癌细胞获得成纤维细胞样迁移特性。然而，越来越明显的是，一些癌细胞以类似于白细胞的阿米巴样方式移动。这一主题将是本综述的重点，我们将讨论癌细胞和白细胞穿过实质基底膜、在间质组织中移动以及进入和离开脉管系统所使用的机制之间的异同。此外，我们提出，能够在不同的迁移机制之间切换对于细胞从一个组织转移到另一个组织至关重要。
