Williams H C, Buffham R, du Vivier A
Department of Dermatology, King's College Hospital, Denmark Hill, London, England.
Arch Dermatol. 1991 Jul;127(7):1023-8.
A double-blind controlled study was performed on a patient with long-standing yellow nail syndrome to investigate the potential beneficial role of topical vitamin E solution for the nail changes seen in this disorder. Three nails received active solution containing DL-alpha-tocopherol in dimethyl sulfoxide; three nails received dimethyl sulfoxide only; and the remainder were untreated. After 6 months of therapy, the three nails treated with active solution showed marked clinical improvement and a corresponding increase in nail growth rates. Dimethyl sulfoxide alone produced a small increase in nail growth rate and slight clinical improvement. Active solution was then applied to all of the nails for a further 6 months, resulting in clinical improvement and increased nail growth rates in the remaining nails. These beneficial effects require further study.
对一名患有长期黄甲综合征的患者进行了一项双盲对照研究，以调查外用维生素E溶液对该疾病中所见指甲变化的潜在有益作用。三个指甲接受含有二甲基亚砜中DL-α-生育酚的活性溶液；三个指甲仅接受二甲基亚砜；其余指甲未接受治疗。治疗6个月后，用活性溶液治疗的三个指甲显示出明显的临床改善，指甲生长速度相应增加。单独使用二甲基亚砜使指甲生长速度略有增加，临床改善轻微。然后将活性溶液应用于所有指甲再持续6个月，其余指甲也出现了临床改善和指甲生长速度增加。这些有益效果需要进一步研究。
