Isozaki Takeo, Yajima Nobuyuki, Sato Michihito, Takahashi Ryo, Wakabayashi Kuninobu, Miwa Yusuke, Negishi Masao, Ide Hirotsugu, Kasama Tsuyoshi
Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Clin Med Insights Case Rep. 2010;3:63-8. doi: 10.4137/CCRep.S5514. Epub 2010 Oct 14.
We report a case of a 67-year-old woman with rheumatoid arthritis with yellow nail syndrome (YNS) that was caused by bucillamine. All three signs (yellow fingernails, lymphatic edema, and bronchiectasis) of YNS manifested, with characteristic timing, first with the nails turning yellow after when bronchiectasis was noticed. We reviewed 10 case reports from Japan and compared the periods until the appearance of yellow nails after starting bucillamine treatment, as well as those until lung disease and leg edema appeared.