儿童年龄组舌鳞状细胞癌：生存情况的配对分析
Squamous cell carcinoma of the oral tongue in the pediatric age group: a matched-pair analysis of survival.
作者信息
Morris Luc G T, Patel Snehal G, Shah Jatin P, Ganly Ian
机构信息
Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA.
出版信息
Arch Otolaryngol Head Neck Surg. 2010 Jul;136(7):697-701. doi: 10.1001/archoto.2010.94.
OBJECTIVE
To compare outcomes of a pediatric cohort of patients compared with a matched cohort of adult patients, all diagnosed as having squamous cell carcinoma (SCC) of the oral tongue. Outcomes of oral cancer in pediatric patients have not been studied, to our knowledge.
DESIGN
Retrospective matched-pair cohort study.
SETTING
Memorial Sloan-Kettering Cancer Center, New York, New York.
PATIENTS
A total of 10 pediatric and 40 adult patients diagnosed as having SCC of the oral tongue.
MAIN OUTCOME MEASURES
Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).
RESULTS
The 5-year OS was equivalent in the 2 groups: 70% in the pediatric group and 64% in the adult group (P = .97). The 5-year DSS was also equivalent: 80% in the pediatric group and 76% in the adult group (P = .90). The 5-year RFS was 70% in the pediatric group and 78% in the adult group (P = .54).
CONCLUSIONS
When pediatric and adult patients were matched for sex, tobacco use history, TNM status, surgical procedure, and adjuvant radiotherapy, outcomes for OS, DSS, and RFS were equivalent. Pediatric patients with SCC of the oral tongue should be treated similarly to adult patients.
目的
比较一组小儿口腔舌鳞状细胞癌（SCC）患者与一组匹配的成年患者的治疗结果。据我们所知，尚未对小儿口腔癌患者的治疗结果进行过研究。
设计
回顾性配对队列研究。
地点
纽约市纪念斯隆-凯特琳癌症中心。
患者
共有10例小儿患者和40例成年患者被诊断为口腔舌SCC。
主要观察指标
总生存期（OS）、疾病特异性生存期（DSS）和无复发生存期（RFS）。
结果
两组的5年OS相当：小儿组为70%，成年组为64%（P = 0.97）。5年DSS也相当：小儿组为80%，成年组为76%（P = 0.90）。小儿组的5年RFS为70%，成年组为78%（P = 0.54）。
结论
当小儿患者和成年患者在性别、吸烟史、TNM分期、手术方式和辅助放疗方面相匹配时，OS、DSS和RFS的结果相当。小儿口腔舌SCC患者的治疗应与成年患者相似。
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