Department of Oral Diagnosis Piracicaba Dental School, University of Campinas 901, Limeira Avenue, PO box 52 Piracicaba, São Paulo 13414-903, Brazil
Med Oral Patol Oral Cir Bucal. 2024 Nov 1;29(6):e791-e796. doi: 10.4317/medoral.26740.
This retrospective study investigates the clinicopathological features and outcomes of young and elderly patients diagnosed with lip squamous cell carcinoma (LSCC).
Data from LSCC patients from Dr. Luiz Antonio Hospital in Natal, Brazil (2000-2015) were analyzed, grouping individuals below 40 and above 60 years old. Demographics, lifestyle habits, clinicopathologic characteristics, and treatment outcomes were examined using descriptive statistics, Chi-square and Fisher's tests, and Kaplan-Meier survival analysis.
A total of 47 patients was analyzed, being 20 younger and 27 older, finding significant age-related differences (p = < 0.0001). Although in both groups the tumor was more common in males, older patients had a higher rate of females (29.6%) (p=0.0358) and smoking (70.4%) (p = 0.0043) and underwent more modalities of treatments (p = 0.0027). There were no significant differences in the other analyzed clinicopathologic factors, and survival rates did not differ significantly, though younger patients showed slightly better survival metrics in univariate analysis.
LSCC exhibits some distinct clinicopathological features across different age groups, with significant differences in treatment modalities and progression rates. Age-specific approaches may be required to optimize treatment outcomes.
本回顾性研究调查了年轻和老年患者唇鳞状细胞癌（LSCC）的临床病理特征和结局。
分析了巴西纳塔尔的 Luiz Antonio 医院（2000-2015 年）的 LSCC 患者数据，将年龄在 40 岁以下和 60 岁以上的患者分组。使用描述性统计、卡方和 Fisher 检验以及 Kaplan-Meier 生存分析检查人口统计学、生活方式习惯、临床病理特征和治疗结果。
共分析了 47 例患者，其中 20 例年龄较小，27 例年龄较大，发现年龄相关差异具有统计学意义（p<0.0001）。尽管两组中肿瘤在男性中更为常见，但老年患者中女性（29.6%）（p=0.0358）和吸烟者（70.4%）（p=0.0043）的比例更高，接受的治疗方式也更多（p=0.0027）。在其他分析的临床病理因素中没有显著差异，生存率也没有显著差异，尽管年轻患者在单因素分析中显示出略高的生存指标。
LSCC 在不同年龄组中表现出一些独特的临床病理特征，在治疗方式和进展率方面存在显著差异。可能需要针对特定年龄的方法来优化治疗结果。
