Zhang Yan-Yan, Wang Dian-Can, Su Jia-Zeng, Jia Ling-Fei, Peng Xin, Yu Guang-Yan
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China.
Head Neck. 2017 Nov;39(11):2276-2282. doi: 10.1002/hed.24898. Epub 2017 Aug 26.
The clinicopathological features and outcomes of squamous cell carcinoma (SCC) of the tongue in patients of different age groups remain debatable.
Medical records of 457 patients with tongue SCC were reviewed, grouped by age, followed up, and compared.
Sex and TNM stage showed no intergroup differences. Tongue SCC in patients ≤30 years had the most advanced TNM classification and greatest proportion of poorly differentiation tumors. Both disease-free survival (DFS) and disease-specific survival (DSS) showed no statistically significant difference between the youngest and the oldest groups (P = .605 and P = .520). However, there was a tendency of higher death rate caused by recurrence or metastasis in the youngest group compared with the others (91.7% vs 75.4% and 77.4%).
Young patients had a tendency of higher death rate caused by recurrence or metastasis than middle-age and older patients; therefore, a larger case sample is needed for further confirmation.
不同年龄组舌鳞状细胞癌（SCC）患者的临床病理特征及预后仍存在争议。
回顾457例舌SCC患者的病历，按年龄分组，进行随访并比较。
性别和TNM分期在组间无差异。≤30岁患者的舌SCC具有最晚期的TNM分类和最高比例的低分化肿瘤。最年轻组和最年长组的无病生存期（DFS）和疾病特异性生存期（DSS）均无统计学显著差异（P = 0.605和P = 0.520）。然而，最年轻组因复发或转移导致的死亡率有高于其他组的趋势（91.7%对75.4%和77.4%）。
年轻患者因复发或转移导致的死亡率有高于中年和老年患者的趋势；因此，需要更大的病例样本进行进一步证实。
