Institut für Physikalische Chemie, Johannes-Gutenberg Universitaet, Welderweg 11, 55099 Mainz, Germany.
Nanoscale. 2010 Jun;2(6):829-43. doi: 10.1039/c0nr00028k. Epub 2010 Mar 29.
Ten years ago I wrote a review about the important field of core-shell nanoparticles, focussing mainly on our own work about tracer systems, and briefly addressing polymer-coated nanoparticles as fillers for homogeneous polymer-colloid composites. Since then, the potential use of core-shell nanoparticles as multifunctional sensors or potential smart drug-delivery vehicles in biology and medicine has gained more and more importance, affording special types of multi-functionalized and bio-compatible nanoparticles. In this new review article, I try to address the most important developments during the last ten years. This overview is mainly based on frequently cited and more specialized recent review articles from leaders in their respective field. We will consider a variety of nanoscopic core-shell architectures from highly fluorescent nanoparticles (NPs), protected magnetic NPs, multifunctional NPs, thermoresponsive NPs and biocompatible systems to, finally, smart drug-delivery systems.
十年前，我写过一篇关于核壳纳米粒子这一重要领域的综述，主要聚焦于我们自己关于示踪系统的工作，并简要介绍了聚合物包覆的纳米粒子作为均相聚合物-胶体复合材料的填充剂。自那时以来，核壳纳米粒子作为多功能传感器或在生物学和医学中作为潜在智能药物输送载体的潜在用途变得越来越重要，提供了特殊类型的多功能化和生物相容性纳米粒子。在这篇新的综述文章中，我尝试总结过去十年中最重要的进展。本综述主要基于各自领域的领导者经常引用的更专业的近期综述文章。我们将考虑各种纳米级核壳结构，包括高荧光纳米粒子（NPs）、受保护的磁性 NPs、多功能 NPs、温度响应性 NPs 和生物相容性系统，最后是智能药物输送系统。
