Department of Internal Medicine, I-Shou University, Kaohsiung, Taiwan.
Br J Surg. 2010 Oct;97(10):1541-6. doi: 10.1002/bjs.7179.
The aim of this study was to evaluate the effects of Roux-en-Y gastric bypass for morbid obesity on health-related quality of life (QOL) during the first year of follow-up.
The World Health Organization Quality of Life-Brief (WHOQOL-BREF) was administered 1 month before operation, and at 1, 3, 6 and 12 months after surgery. Body mass index, co-morbidities and operation-related complications were measured at these times. A mixed-effect model was constructed to analyse repeated measurements and determine the relationships between body mass index, WHOQOL-BREF scores and other variables.
A total of 102 patients were enrolled. The mixed-effect model showed that the physical, psychological and social domains improved after bariatric surgery, with simultaneous reduction in weight and improvement in co-morbidities. There was a dip in scores in physical and psychological domains 3-6 months after surgery, significantly related to complications. All patients gradually improved between 6 and 12 months after surgery, reaching levels similar to those of healthy subjects.
Health-related QOL improved dramatically after bariatric surgery, dipped slightly between 3 and 6 months, and improved again up to the end of the first year.
本研究旨在评估肥胖症患者行 Roux-en-Y 胃旁路术对健康相关生活质量（QOL）的影响，随访时间为 1 年。
术前 1 个月、术后 1、3、6 和 12 个月时采用世界卫生组织生活质量简表（WHOQOL-BREF）进行评估。同时测量体重指数、合并症和手术相关并发症。采用混合效应模型分析重复测量值，并确定体重指数、WHOQOL-BREF 评分与其他变量之间的关系。
共纳入 102 例患者。混合效应模型显示，减肥手术后患者的身体、心理和社会领域得到改善，同时体重减轻，合并症改善。术后 3-6 个月，身体和心理领域的评分略有下降，与并发症显著相关。所有患者在术后 6-12 个月逐渐改善，达到与健康受试者相似的水平。
减肥手术后健康相关 QOL 显著改善，术后 3-6 个月略有下降，至术后 1 年时再次改善。
