School of Biological Sciences, The University of Queensland, Brisbane, Australia.
Trends Parasitol. 2010 Aug;26(8):373-5. doi: 10.1016/j.pt.2010.05.006. Epub 2010 Jun 16.
Wolbachia pipientis are maternally inherited, endosymbiotic bacteria that are widespread among insects. Two recent studies have demonstrated that Wolbachia inhibits the ability of medically significant pathogens, including filarial nematodes, dengue virus and Plasmodium to form infections in the mosquito vector, Aedes aegypti. We highlight the added value of these traits for Wolbachia based biocontrol strategies and evaluate the evidence for the idea that the insect immune response is responsible for the pathogen inhibition.
沃尔巴克氏体是一种母系遗传的内共生细菌，广泛存在于昆虫中。最近的两项研究表明，沃尔巴克氏体抑制了医学上重要的病原体（包括丝虫、登革热病毒和疟原虫）在蚊子媒介埃及伊蚊中形成感染的能力。我们强调了这些特性对基于沃尔巴克氏体的生物控制策略的附加值，并评估了昆虫免疫反应负责抑制病原体的观点的证据。
