Department of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, India.
Int J Endocrinol. 2010;2010:841090. doi: 10.1155/2010/841090. Epub 2010 Jun 22.
The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of beta-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity.
本研究旨在评估长春花甲醇全植物提取物在四氧嘧啶诱导的糖尿病大鼠中的抗糖尿病活性，为期 14 天。在糖尿病大鼠中，高剂量（500mg/kg）的甲醇全植物提取物比低剂量（300mg/kg）的全植物提取物表现出显著的降血糖活性。甲醇提取物还改善了糖尿病大鼠的体重和血脂谱等参数，并促进了胰腺β细胞的再生。组织病理学研究证实，甲醇长春花提取物具有愈合胰腺的作用，这可能是其抗糖尿病活性的一种机制。
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