Sarrouy J, Cellier C, Migliani R, Todesco A, Favier G, Linden L, Pull J, Pascal B, Baudon D, Delolme H
CHA H. Larrey, 31998 Toulouse Armées.
Bull Soc Pathol Exot. 1991;84(1):80-93.
Incidence of P. falciparum malaria in french non-immune soldiers serving in Gabon for four months has increased from 21% in 1987 to 37% in 1988. Since 1989, in a first step, the personal protection measures were reinforced. Thereafter, the usual chemoprophylaxis (chloroquine 100 mg daily) was replaced by a daily association of chloroquine 100 mg and proguanil 200 mg. A 85% decrease of malaria incidence was observed in 431 soldiers. The effects of the personal protection strengthening and of the new chemoprophylaxis can be evaluated to be respectively responsible for 50% and 71% decrease. Among the secondary effects, gastric pain was the most frequent, but it was never a cause of chemoprophylaxis stopping. The mouth ulcer frequency was far lower than that elsewhere reported. No significant biological abnormalities could be related to the chloroquine-proguanil association.
在加蓬服役四个月的法国非免疫士兵中，恶性疟原虫疟疾的发病率从1987年的21%上升到了1988年的37%。自1989年起，首先加强了个人防护措施。此后，常规的化学预防（每日100毫克氯喹）被每日联合使用100毫克氯喹和200毫克氯胍所取代。在431名士兵中观察到疟疾发病率下降了85%。个人防护加强和新的化学预防措施的效果分别被评估为导致发病率下降50%和71%的原因。在次要影响中，胃痛最为常见，但从未因此导致停止化学预防。口腔溃疡的发生率远低于其他地方报道的水平。没有发现与氯喹-氯胍联合使用相关的明显生物学异常。
