Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Biochem Pharmacol. 2010 Dec 15;80(12):1833-43. doi: 10.1016/j.bcp.2010.07.021. Epub 2010 Jul 21.
Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer. Various nutraceuticals from fruits, vegetables, vitamins, spices, legumes, and traditional Chinese and Ayurvedic medicine have been shown to safely suppress proinflammatory pathways; however, their low bioavailability in vivo limits their use in preventing and treating cancer. We describe here the potential of nanotechnology to fill this gap. Several nutraceuticals, including curcumin, green tea polyphenols, coenzyme Q, quercetin, thymoquinone and others, have been packaged as nanoparticles and proven to be useful in "nanochemoprevention" and "nano-chemotherapy".
在过去的二十年中，广泛的研究揭示了大多数慢性疾病，包括癌症、糖尿病、心血管和肺部疾病，都是通过慢性炎症介导的。因此，抑制慢性炎症有可能延缓、预防甚至治疗各种慢性疾病，包括癌症。各种来自水果、蔬菜、维生素、香料、豆类和中药及阿育吠陀医学的营养保健品已被证明能够安全地抑制促炎途径；然而，它们在体内的低生物利用度限制了它们在预防和治疗癌症中的应用。我们在这里描述了纳米技术填补这一空白的潜力。几种营养保健品，包括姜黄素、绿茶多酚、辅酶 Q、槲皮素、百里醌等，已被包装成纳米颗粒，并已被证明在“纳米化学预防”和“纳米化疗”中有用。
