Nguyen T D, Cornillet-Stoupy J, Gillery P, Maquart F X
Service de Radiothérapie (Radiothérapie Expérimentale), Institut Jean-Godinot, Reims, France.
Experientia. 1991 Jul 15;47(7):725-8. doi: 10.1007/BF01958827.
Dermal equivalents (DE), collagen lattices, were produced in vitro and used as a model for studying the possible role of a pure population of fibroblasts in post-radiotherapeutic dermal fibrosis. Single doses of gamma irradiation induced a partial inhibition of the collagen lattice retraction and of protein synthesis. The collagen production was less inhibited than was synthesis of non-collagen protein, which resulted in an increase of the relative amount of collagen synthesized by irradiated fibroblasts. These data suggest that gamma irradiation might be able to select some fibroblast clones able to produce increasing amounts of collagen. This selection process could be involved in the development of tissue fibrosis after therapeutic radiation.
在体外制备了真皮替代物（DE），即胶原晶格，并将其用作研究纯成纤维细胞群体在放射治疗后皮肤纤维化中可能作用的模型。单剂量γ射线照射可部分抑制胶原晶格收缩和蛋白质合成。胶原生成的受抑制程度低于非胶原蛋白质的合成，这导致受照射成纤维细胞合成的胶原相对量增加。这些数据表明，γ射线照射可能能够选择一些能够产生更多胶原的成纤维细胞克隆。这一选择过程可能参与了治疗性放疗后组织纤维化的发展。
