从细叶黄杨中提取的三萜生物碱。

Triterpenoid alkaloids from Buxus microphylla.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China.

出版信息

Chem Biodivers. 2010 Jul;7(7):1822-7. doi: 10.1002/cbdv.200900259.

DOI:10.1002/cbdv.200900259

PMID:20658671

Abstract

Two new triterpenoid alkaloids, buxmicrophyllines J and K (1 and 2, resp.), together with four analogues, 3-6, were isolated from the leaves and stems of Buxus microphylla. The structures of the new compounds were elucidated by NMR and MS spectroscopic analyses. The partial assignments of the NMR spectra of 3 were also revised. Compounds 1 and 3-6 were evaluated for their growth inhibitory activity against human cell lines HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1. Compound 6 showed significant cytotoxicity against HL-60, SK-BR-3, and PANC-1 cell lines, with IC(50) values of 6.46, 19.61, and 28.57 microM, respectively.

摘要

从小叶榕的叶和茎中分离得到了两个新的三萜生物碱，布克斯微菲林 J 和 K（1 和 2），以及四个类似物 3-6。通过 NMR 和 MS 光谱分析阐明了新化合物的结构。还修正了 3 的 NMR 谱的部分分配。对化合物 1 和 3-6 进行了对人细胞系 HL-60、SMMC-7721、A-549、SK-BR-3 和 PANC-1 的生长抑制活性评估。化合物 6 对 HL-60、SK-BR-3 和 PANC-1 细胞系表现出显著的细胞毒性，IC(50)值分别为 6.46、19.61 和 28.57 microM。