小叶黄杨中三萜生物碱对人肿瘤细胞系的细胞毒性

Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines.

作者信息

Bai Shi-Tou, Zhu Guo-Lei, Peng Xing-Rong, Dong Jin-Run, Yu Mu-Yuan, Chen Jian-Chao, Wan Luo-Sheng, Qiu Ming-Hua

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.

出版信息

Molecules. 2016 Aug 26;21(9):1125. doi: 10.3390/molecules21091125.

DOI:10.3390/molecules21091125

PMID:27571056

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6273435/

Abstract

Three new triterpenoid alkaloids, namely buxmicrophyllines P-R (1-3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 1-3 belong to the 9,10-cycloartane type alkaloids. In addition, compound 3 exhibited moderate cytotoxic activities in vitro against HL-60, SMMC-7221, A-549, MCF-7, and SW480 cell lines (with IC50 values ranging from 4.51 to 15.58 μM).

摘要

从小叶黄杨的嫩枝和叶片中分离得到了三种新的三萜生物碱，即小叶黄杨碱P - R（1 - 3）。通过核磁共振（NMR）和质谱（MS）光谱分析确定了它们的结构。在结构上，化合物1 - 3属于9,10 - 环阿尔廷型生物碱。此外，化合物3在体外对HL - 60、SMMC - 7221、A - 549、MCF - 7和SW480细胞系表现出中等程度的细胞毒性活性（IC50值范围为4.51至15.58 μM）。