四棱豆果实中的一种新型喹诺酮类化合物及其他成分：对中性粒细胞促炎反应的影响。
A new quinolone and other constituents from the fruits of Tetradium ruticarpum: effects on neutrophil pro-inflammatory responses.
机构信息
Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
出版信息
Chem Biodivers. 2010 Jul;7(7):1828-34. doi: 10.1002/cbdv.200900289.
The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2-[(6Z,9Z)-pentadeca-6,9-dienyl]quinolin-4(1H)-one (1), has been isolated from the fruits of T. ruticarpum, together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine (4), evodiamine (5), and skimmianine (7) exhibited inhibition (IC(50) < or = 20.9 microM) of O2(.-) generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, 1, evocarpine (2), 4, 7, and evodol (8) inhibited fMLP/CB-induced elastase release with IC(50) values < or =14.4 microM.
枳椇子的果实广泛应用于保健品中，用于改善血液循环、头痛、腹痛、闭经、四肢发冷、偏头痛和恶心。一种新的喹诺酮类化合物，2-[(6Z,9Z)-十五烷-6,9-二烯基]喹啉-4(1H)-酮（1），已从枳椇子的果实中分离出来，同时还分离出了 11 种已知化合物。新化合物的结构通过 NMR 和 MS 分析确定。山小橘碱（4）、吴茱萸碱（5）和千金藤碱（7）对 N-甲酰基-L-甲硫氨酸-L-亮氨酸-L-苯丙氨酸/细胞松弛素 B（fMLP/CB）刺激的人中性粒细胞中 O2(-)生成具有抑制作用（IC50 <或= 20.9 microM）。此外，化合物 1、evocarpine（2）、4、7 和 evodol（8）对 fMLP/CB 诱导的弹性蛋白酶释放具有抑制作用，IC50 值<或=14.4 microM。
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