MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Biochem Soc Trans. 2010 Aug;38(4):879-82. doi: 10.1042/BST0380879.
Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their assembly in solution.
同型寡聚蛋白复合物在活细胞中具有重要的功能和高度丰富性。在本文中,我们回顾了我们目前对它们的几何形状和进化的理解,包括这些复合物的对称性和它们的相互作用界面的各个方面。此外,我们还简要讨论了它们在溶液中的组装途径。