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社区贫困程度、种族构成与肾脏移植候补者名单。

Neighborhood poverty, racial composition and renal transplant waitlist.

机构信息

Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.

出版信息

Am J Transplant. 2010 Aug;10(8):1912-7. doi: 10.1111/j.1600-6143.2010.03206.x.

Abstract

To date, no study has characterized the association between neighborhood poverty, racial composition and deceased donor kidney waitlist. Using the United States Renal Data System data linked to 2000 U.S. Census Data, we examined Whites (n = 152 788) and Blacks (n = 130 300) initiating dialysis between January 2000 and December 2006. Subjects' neighborhoods were divided into nine strata based on the percent of Black residents and percent poverty. Cox proportional hazards were used to determine the association between time to waitlist and neighborhood characteristics after adjusting for demographics and comorbid conditions. Individuals from poorer neighborhoods had a consistently lower likelihood of being waitlisted. This association was synergistic with neighborhood racial composition for Blacks, but not for Whites. Blacks in poor, predominantly Black neighborhoods (adjusted hazard ratio [HR] 0.57, 95% confidence intervals [CI] 0.53-0.62) were less likely to appear on transplant waitlist than those in wealthy, predominantly Black neighborhoods (HR 0.80, CI 0.67-0.96) and poor, predominantly White neighborhoods (HR 0.79, CI 0.70-0.89). All were all less likely to be waitlisted than their Black counterparts in wealthy, predominantly White or mixed neighborhoods (p < 0.05). Interventions targeted at individuals in poor and minority neighborhoods may represent an opportunity to improve equitable access to the deceased donor kidney waitlist.

摘要

迄今为止,尚无研究描述社区贫困程度、种族构成与已故供者肾脏等待移植者名单之间的关系。我们利用美国肾脏数据系统(United States Renal Data System)与 2000 年美国人口普查数据(2000 U.S. Census Data)相链接的数据,调查了在 2000 年 1 月至 2006 年 12 月期间开始透析的白人(n = 152788)和黑人(n = 130300)。根据黑人居民比例和贫困率,将受试者的社区分为九个层次。采用 Cox 比例风险模型,在调整人口统计学和合并症后,确定等待移植名单的时间与社区特征之间的关系。来自贫困社区的个体等待移植的可能性始终较低。这种关联对于黑人来说与社区种族构成具有协同作用,但对于白人来说则不然。居住在贫困、黑人为主的社区(调整后的危险比[HR]为 0.57,95%置信区间[CI]为 0.53-0.62)的黑人比居住在富裕、黑人为主的社区(HR 为 0.80,CI 为 0.67-0.96)和贫困、白人为主的社区(HR 为 0.79,CI 为 0.70-0.89)的黑人更不可能出现在移植等待名单上。与富裕的白人或混合社区的黑人相比,他们所有人出现在等待名单上的可能性都较低(p < 0.05)。针对贫困和少数族裔社区的个体的干预措施可能是改善公平获得已故供者肾脏等待移植名单的机会。

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