Saunders Milda R, Lee Haena, Alexander G Caleb, Tak Hyo Jung, Thistlethwaite J Richard, Ross Lainie Friedman
Department of Medicine, Section of Hospital Medicine, University of Chicago Medical Center, Chicago, IL, USA.
MacLean Center for Clinical Medical Ethics, University of Chicago Medical Center, Chicago, IL, USA.
Clin Transplant. 2015 Jun;29(6):531-8. doi: 10.1111/ctr.12547. Epub 2015 Apr 27.
In the United States, African Americans and whites differ in access to the deceased donor renal transplant waitlist. The extent to which racial disparities in waitlisting differ between United Network for Organ Sharing (UNOS) regions is understudied.
The US Renal Data System (USRDS) was linked with US census data to examine time from dialysis initiation to waitlisting for whites (n = 188,410) and African Americans (n = 144,335) using Cox proportional hazards across 11 UNOS regions, adjusting for potentially confounding individual, neighborhood, and state characteristics.
Likelihood of waitlisting varies significantly by UNOS region, overall and by race. Additionally, African Americans face significantly lower likelihood of waitlisting compared to whites in all but two regions (1 and 6). Overall, 39% of African Americans with ESRD reside in Regions 3 and 4--regions with a large racial disparity and where African Americans comprise a large proportion of the ESRD population. In these regions, the African American-white disparity is an important contributor to their overall regional disparity.
Race remains an important factor in time to transplant waitlist in the United States. Race contributes to overall regional disparities; however, the importance of race varies by UNOS region.
在美国,非裔美国人和白人在进入已故捐赠者肾移植等待名单的机会方面存在差异。器官共享联合网络(UNOS)各地区在等待名单上的种族差异程度尚未得到充分研究。
美国肾脏数据系统(USRDS)与美国人口普查数据相链接,以使用Cox比例风险模型,在11个UNOS地区研究白人(n = 188,410)和非裔美国人(n = 144,335)从开始透析到进入等待名单的时间,并对潜在的个体、社区和州特征混杂因素进行调整。
等待名单的可能性在UNOS各地区之间总体以及按种族存在显著差异。此外,除了两个地区(1区和6区)外,非裔美国人进入等待名单的可能性明显低于白人。总体而言,39%的终末期肾病(ESRD)非裔美国人居住在3区和4区,这两个地区种族差异大,且非裔美国人在ESRD人群中占很大比例。在这些地区,非裔美国人和白人之间的差异是其总体地区差异的一个重要因素。
种族仍然是美国进入移植等待名单时间的一个重要因素。种族导致了总体地区差异;然而,种族的重要性因UNOS地区而异。