Laboratorium voor Neurofysiologie en Psychofysiologie, Katholieke Universiteit Leuven Medical School, Campus Gasthuisberg, 3000 Leuven, Belgium.
J Neurosci. 2010 Jul 21;30(29):9801-20. doi: 10.1523/JNEUROSCI.2069-10.2010.
Although there is general agreement that the human middle temporal (MT)/V5+ complex corresponds to monkey area MT/V5 proper plus a number of neighboring motion-sensitive areas, the identification of human MT/V5 within the complex has proven difficult. Here, we have used functional magnetic resonance imaging and the retinotopic mapping technique, which has very recently disclosed the organization of the visual field maps within the monkey MT/V5 cluster. We observed a retinotopic organization in humans very similar to that documented in monkeys: an MT/V5 cluster that includes areas MT/V5, pMSTv (putative ventral part of the medial superior temporal area), pFST (putative fundus of the superior temporal area), and pV4t (putative V4 transitional zone), and neighbors a more ventral putative human posterior inferior temporal area (phPIT) cluster. The four areas in the MT/V5 cluster and the two areas in the phPIT cluster each represent the complete contralateral hemifield. The complete MT/V5 cluster comprises 70% of the motion localizer activation. Human MT/V5 is located in the region bound by lateral, anterior, and inferior occipital sulci and occupies only one-fifth of the motion complex. It shares the basic functional properties of its monkey homolog: receptive field size relative to other areas, response to moving and static stimuli, as well as sensitivity to three-dimensional structure from motion. Functional properties sharply distinguish the MT/V5 cluster from its immediate neighbors in the phPIT cluster and the LO (lateral occipital) regions. Together with similarities in retinotopic organization and topological neighborhood, the functional properties suggest that MT/V5 in human and macaque cortex are homologous.
尽管人们普遍认为人类中颞(MT)/V5+复合体对应于猴子的 MT/V5 区域以及一些相邻的运动敏感区域,但在该复合体中识别人类的 MT/V5 却非常困难。在这里,我们使用了功能磁共振成像和视网膜映射技术,该技术最近揭示了猴子 MT/V5 簇内的视野图谱的组织。我们观察到人类的视网膜组织与猴子的非常相似:一个 MT/V5 簇,包括 MT/V5、pMSTv(内侧上颞区的假定腹侧部分)、pFST(假定上颞区底部)和 pV4t(假定 V4 过渡区),以及相邻的更腹侧的假定人类后颞下区(phPIT)簇。MT/V5 簇中的四个区域和 phPIT 簇中的两个区域每个都代表了完整的对侧视野。完整的 MT/V5 簇占运动定位器激活的 70%。人类的 MT/V5 位于外侧、前侧和下枕骨沟之间的区域,仅占运动复合体的五分之一。它具有与猴子同源物相同的基本功能属性:相对于其他区域的感受野大小、对运动和静态刺激的反应以及对运动的三维结构的敏感性。功能特性将 MT/V5 簇与其在 phPIT 簇和 LO(外侧枕叶)区域中的直接邻居明显区分开来。与视网膜组织和拓扑邻域的相似性一起,功能特性表明人类和猕猴皮层中的 MT/V5 是同源的。