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Dictyostelium finds new roles to model.粘菌找到了新的角色来建模。
Genetics. 2010 Jul;185(3):717-26. doi: 10.1534/genetics.110.119297.
2
dictyBase, the model organism database for Dictyostelium discoideum.盘基网柄菌模式生物数据库(dictyBase),用于盘基网柄菌。
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Co-occurrence in nature of different clones of the social amoeba, Dictyostelium discoideum.社会变形虫盘基网柄菌不同克隆在自然界中的共生现象。
Mol Ecol. 2003 Apr;12(4):1031-8. doi: 10.1046/j.1365-294x.2003.01792.x.
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Crawling into a new era-the Dictyostelium genome project.迈入新时代——盘基网柄菌基因组计划
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Dictyostelium as host model for pathogenesis.盘基网柄菌作为发病机制的宿主模型。
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The past, present and future of Dictyostelium as a model system.盘基网柄菌作为一种模式生物的过去、现在与未来。
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[Dictyostelium. A social amoeba as a model organism].[盘基网柄菌。作为模式生物的社会性变形虫]
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Chromosome-level genome assembly and annotation of the social amoeba Dictyostelium firmibasis.社会变形虫 Dictyostelium firmibasis 的染色体水平基因组组装和注释。
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Evolution of microRNAs in Amoebozoa and implications for the origin of multicellularity.变形虫中 microRNAs 的进化及其对多细胞起源的意义。
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ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation.ATP 水平通过 ATP 可视化和模拟揭示了在盘基网柄菌的丘阶段影响细胞运动。
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本文引用的文献

1
Recent insights into host-pathogen interactions from Dictyostelium.从黏菌看宿主-病原体相互作用的新认识。
Cell Microbiol. 2010 Mar;12(3):283-91. doi: 10.1111/j.1462-5822.2009.01413.x. Epub 2009 Nov 16.
2
Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells.肺炎军团菌增殖是由线粒体病变的 Dictyostelium 细胞中慢性 AMPK 信号增强的。
Dis Model Mech. 2009 Sep-Oct;2(9-10):479-89. doi: 10.1242/dmm.003319. Epub 2009 Jul 28.
3
Transcriptional down-regulation and rRNA cleavage in Dictyostelium discoideum mitochondria during Legionella pneumophila infection.嗜肺军团菌感染期间盘基网柄菌线粒体中的转录下调和核糖体RNA切割
PLoS One. 2009 May 27;4(5):e5706. doi: 10.1371/journal.pone.0005706.
4
Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium.从盘基网柄菌中分离出的含嗜肺军团菌吞噬体的蛋白质组学分析。
Int J Med Microbiol. 2009 Nov;299(7):489-508. doi: 10.1016/j.ijmm.2009.03.006. Epub 2009 May 23.
5
Activated cAMP receptors switch encystation into sporulation.激活的环磷酸腺苷(cAMP)受体将包囊化转变为孢子形成。
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7089-94. doi: 10.1073/pnas.0901617106. Epub 2009 Apr 14.
6
Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts.结核分枝杆菌的感染是通过从其变形虫宿主中以非裂解方式排出而传播的。
Science. 2009 Mar 27;323(5922):1729-33. doi: 10.1126/science.1169381.
7
Phagocytosis and host-pathogen interactions in Dictyostelium with a look at macrophages.盘基网柄菌中的吞噬作用及宿主-病原体相互作用,并着眼于巨噬细胞
Int Rev Cell Mol Biol. 2008;271:253-300. doi: 10.1016/S1937-6448(08)01206-9.
8
A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling.后生动物Cbl蛋白的盘基网柄菌同源物调节STAT信号传导。
J Cell Sci. 2008 Nov 1;121(Pt 21):3524-30. doi: 10.1242/jcs.036798. Epub 2008 Oct 7.
9
Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains.盘基网柄菌对铜绿假单胞菌的转录反应:PAO1和PA14菌株的共同及特异性影响
BMC Microbiol. 2008 Jun 30;8:109. doi: 10.1186/1471-2180-8-109.
10
Eat, kill or die: when amoeba meets bacteria.进食、杀灭或死亡:当变形虫遇到细菌时。
Curr Opin Microbiol. 2008 Jun;11(3):271-6. doi: 10.1016/j.mib.2008.05.005. Epub 2008 Jun 10.

粘菌找到了新的角色来建模。

Dictyostelium finds new roles to model.

机构信息

College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

出版信息

Genetics. 2010 Jul;185(3):717-26. doi: 10.1534/genetics.110.119297.

DOI:10.1534/genetics.110.119297
PMID:20660652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2907197/
Abstract

Any established or aspiring model organism must justify itself using two criteria: does the model organism offer experimental advantages not offered by competing systems? And will any discoveries made using the model be of wider relevance? This review addresses these issues for the social amoeba Dictyostelium and highlights some of the organisms more recent applications. These cover a remarkably wide gamut, ranging from sociobiological to medical research with much else in between.

摘要

任何既定或有抱负的模式生物都必须用两个标准来证明自己的合理性

该模式生物是否提供了竞争系统所没有提供的实验优势?并且,使用该模型所做出的任何发现是否具有更广泛的相关性?本文针对社会变形虫 Dictyostelium 探讨了这些问题,并强调了该生物最近的一些应用。这些应用涵盖了从社会生物学到医学研究的广泛范围,其间还有许多其他领域。