乳腺癌的分子与功能影像学

Molecular and functional imaging of breast cancer.

机构信息

H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

出版信息

Cancer Control. 2010 Jul;17(3):143-55. doi: 10.1177/107327481001700302.

DOI:10.1177/107327481001700302

PMID:20664511

Abstract

BACKGROUND

Significant efforts have been directed toward developing and enhancing imaging methods for the early detection, diagnosis, and characterization of small breast tumors. Molecular and functional imaging sets the stage for enhancement of current methodology.

METHODS

Current imaging modalities are described based on the molecular characteristics of normal and malignant tissue. New molecular imaging methods that have the potential for clinical use are also discussed.

RESULTS

Dynamic contrast-enhanced magnetic resonance imaging is more sensitive than mammography in BRCA1 carriers. It is used in screening and in the early evaluation of neoadjuvant therapy. Positron emission mammography is 91% sensitive and 93% specific in detecting primary breast cancers. Sentinel node scintigraphy is a key component of axillary lymph node evaluation. Other imaging modalities being studied include Tc99m sestamibi, radiolabeled thymidine or uridine, estrogen receptor imaging, magnetic resonance spectroscopy, and diffusion magnetic resonance imaging.

CONCLUSIONS

Molecular and functional imaging of the breast will likely alter clinical practice in diagnosing and staging primary breast cancer and assessing response to therapy since it will provide earlier information regarding the underlying biology of individual breast cancers, tumor stage, potential treatment strategies, and biomarkers for early evaluation of treatment effects.

摘要

背景

人们已经投入大量精力开发和改进成像方法，以实现对小乳房肿瘤的早期检测、诊断和特征分析。分子和功能成像为改进当前方法奠定了基础。

方法

根据正常组织和恶性组织的分子特征描述了现有的成像方式。还讨论了一些具有潜在临床应用前景的新分子成像方法。

结果

与乳腺摄影术相比，动态对比增强磁共振成像在 BRCA1 携带者中更敏感。它被用于筛查和新辅助治疗的早期评估。正电子发射乳腺摄影术在检测原发性乳腺癌方面的敏感性为 91%，特异性为 93%。前哨淋巴结闪烁显像是腋窝淋巴结评估的关键组成部分。其他正在研究的成像方式包括 Tc99m sestamibi、放射性标记的胸苷或尿苷、雌激素受体成像、磁共振波谱和弥散磁共振成像。