中性粒细胞：肾小球肾炎的改变者？
Neutrophils: game changers in glomerulonephritis?
机构信息
Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
出版信息
Trends Mol Med. 2010 Aug;16(8):368-78. doi: 10.1016/j.molmed.2010.06.002. Epub 2010 Jul 29.
Glomerulonephritides represent a diverse array of diseases that have in common immune cell-mediated effector mechanisms that cause organ damage. The contribution of neutrophils to the pathogenesis of proliferative glomerulonephritis (GN) is not well recognized. Most equate neutrophils with killing pathogens and causing collateral tissue damage during acute inflammation. However, these phagocytes are endowed with additional characteristics that have been traditionally reserved for cells of the adaptive immune system. They communicate with other cells, exhibit plasticity in their responses and have the potential to coordinate and inform the subsequent immune response, thus countering the notion that they arrive, destroy and then disappear. Therefore, neutrophils, which are the first to arrive at a site of inflammation, are potential game changers in GN.
肾小球肾炎是一组具有共同特点的疾病，即免疫细胞介导的效应机制导致器官损伤。中性粒细胞在增生性肾小球肾炎（GN）发病机制中的作用尚未得到充分认识。大多数人认为中性粒细胞在急性炎症期间通过杀死病原体和引起继发性组织损伤来发挥作用。然而，这些吞噬细胞还具有传统上被认为是适应性免疫系统细胞所具有的其他特征。它们与其他细胞进行通讯，在其反应中表现出可塑性，并具有协调和告知随后免疫反应的潜力，从而否定了它们到达、破坏然后消失的观点。因此，中性粒细胞是炎症部位最早到达的细胞，它们在 GN 中可能是潜在的改变游戏规则的因素。
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